Bioassay

oaPHARMACOLOGY rulers and Methods of assay Prof. Ramesh K. Goyal L. M. College of Pharmacy Navrangpura Ahmedabad- 380 009 (18.01.2008) CONTENTS splendour of Bioassay Principle of Bioassay Methods of Bioassay for Agonists Bioassay of Antagonists Bioassay of some Copernican medicates period status of Bioassay in different Pharmacopoeia some other formal Bioassays Keywords Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase,diphtheria vaccine, plague vaccine 1 Bioassay is defined as the estimation of the potency of an wide awake pattern in a unit quantity of homework or detection and step of the concentration of the substance in a preparation employ biological methods (i.e. observation of pharmacological effects on animate tissues, microorganisms or immune cells or animal). Hence micro assay, radioimmunoassay argon also regarded as `bio-assay. tardi ly `biotechnology has also been considered for bioassay. Bioassay of the products wish well erythropoietin, hepatitisB vaccine etcetera is being done through biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g.

chemical or tangible assay) are less(prenominal) accurate, less elaborate, more laborious, more troublesome and more expensive. However, bioassay is the only method of assay if (1) active voice principle of do drugs is unknown or can non be isolated, e.g. insulin, rear pituitary extract etc. (2) Chemical method is some(prenominal) non available or if available, it is too complex and unresponsive or requ! ires higher dose e.g. insulin, acetylcholine. (3) Chemical composition is not known, e.g. long acting thyroid stimulants. (4) Chemical composition of drug differs but have the same pharmacological action and vice-versa, e.g. cardiac glycosides, catecholamines etc. Moreover, even if chemical methods are available and the results of bioassay conflict with those of the chemical assay,...If you want to get a monolithic essay, order it on our website: OrderCustomPaper.com

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